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神経行動薬理若手研究者の集いとともに

疾病薬学研究所 小野寺憲治  YNBPsendai

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薬剤師か薬剤士か?

投稿日: 2014 12月 20、7:54 午後
薬剤師(やくざいし)とは、「調剤医薬品の供給その他薬事衛生をつかさどることによって、公衆衛生の向上及び増進に寄与し、もって国民の健康な生活を確保する任務者であり(薬剤師法第一条)、医薬関係者(薬事法)・医療関係者及び医療従事者としての担い手である(医療法第一条の2)。それゆえ、ただの調剤のテクニシャンではなく、チーム医療の薬の専門家としての師範、先生であるべきであろうというのがコンセプトと思われる。しかし、市中にはこの自覚のある人材ががんばっているのだが、ただ単に調剤スキルだけのテクニシャンが混在しているのも事実であろう。
 最近遭遇した薬剤師の方は、4年生制度の薬剤師で、卒業後あまり勉強していない薬剤師のようであり、平気でセロトニンは習っていないので、片頭痛のメカニズムはわかりませんと弁明いたします。
要するに、大学時代に研究マインドを養成してなかったということです。大学も国家試験の合格率を上げるための演習、練習だけに力を入れて、今までの自分の知識をもとに新しい事実を類推し、判断していくという能力の開発、養成がなされていない。わからないと、すぐ先生に聞いてすますという方がおります。
4年間であろうが、6年間であろうが、この手の新規事実を自分で学んで、理解していこうという気構えがないといけませんね。
ルフィナミドという抗てんかん薬の新薬があり、新規構造のトリアゾール誘導体であり、てんかん発作の原因となる過剰電荷を帯びている脳内ナトリウムチャネルの活動を調節することにより、ナトリウムチャンネルの不活性状態を延長し、抗てんかん作用を示すと考えられています。たとえば、構造のトリアゾールは、1,2,4-Triazole is one of a pair of isomericchemical compounds with molecular formula CHN, called triazoles, which have a five-membered ring of two carbon atoms and three nitrogen atoms. ということですね。この件で、私に向かって質問した某薬科大学卒業者の質問が大丈夫かと思ったのは、triazolesのolはーOH基をさすので、-OH基が構造式にないのでおかしいと言うのです。開いた口がふさがりませんでしたね。
また、別件ですが、嚥下障害が起きていいる患者さんの服用している薬剤を調べましたら、ビペリデン塩酸塩錠とトリヘキシフェニジル塩酸塩錠が配合されていて、口渇が起きやすく、唾液がでないので呑み込みが余計悪くなってきていると思われるのだが、その薬剤師さんは、これらの薬は、パーキンソン病で使うので、中枢選択性が高く、末梢作用は無視できるのではないかと習ったということをおっしゃる。なんという薬理の知識でしょうか。昔の試験は、薬理ができなくても、総合点で受かれば問題にはならなかったのでしょうか?彼にとって、一度覚えた知識は、絶対であり平面的な思考しかできないのだなと思いましたが、、、それはまいりますね。
大学での教育は、1+1=2という平面的教育だけで終わり、その後、2進法があるとか、物を立体的に見なければいけない世界があるのを無視して生きているようである。国家資格をとるために、大脳を使わず、条件反射だけを訓練してきた方は、そんなもんであろうかとびっくりする次第であります。わたしも教育畑におりましたが、現状はひどいものであります。
 

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